Search results for "Growth Hormone-Releasing Hormone"
showing 3 items of 3 documents
GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults.
2008
BackgroundIt is well established that repeated GHRH administration or repeated voluntary exercise bouts are associated with a complete blunting of GH responsiveness when the administration of the second stimulus follows the first one after a 2-h interval.AimTo evaluate GH responses to neuromuscular electrical stimulation (NMES) in healthy adults.MethodsSix volunteers (mean age±s.d. 31.7±5.5 years) were studied before and after two consecutive bouts of NMES exercise (a series of 20 contractions at the maximum of individual tolerance, frequency: 75 Hz, pulse duration: 400 μs, on–off ratio: 6.25–20 s) administered at a 2-h interval.ResultsBaseline GH levels (mean: 0.3±0.2 ng/ml) significantly …
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease.
2010
Endocannabinoids act as neuromodulatory and neuroprotective cues by engaging type 1 cannabinoid receptors. These receptors are highly abundant in the basal ganglia and play a pivotal role in the control of motor behaviour. An early downregulation of type 1 cannabinoid receptors has been documented in the basal ganglia of patients with Huntington's disease and animal models. However, the pathophysiological impact of this loss of receptors in Huntington's disease is as yet unknown. Here, we generated a double-mutant mouse model that expresses human mutant huntingtin exon 1 in a type 1 cannabinoid receptor-null background, and found that receptor deletion aggravates the symptoms, neuropatholog…
Correlation between severity of growth hormone deficiency and thyroid metabolism and effects of long-term growth hormone treatment on thyroid functio…
2013
<b><i>Background/Aim:</i></b> The significance of changes in thyroid function in children during growth hormone (GH) treatment remains uncertain. We aimed to evaluate the impact of GH replacement on thyroid status in children with idiopathic GH deficiency (GHD). <b><i>Methods:</i></b> Data of 105 GHD children (82 M, 23 F; aged 11.13 years) during a 36-month follow-up were analyzed. At diagnosis the areas under the curve of GH (AUC<sub>GH</sub>) were calculated during a GH-releasing hormone + arginine (GHRH-Arg) and insulin tolerance test. <b><i>Results:</i></b> A significant &#x0394;fT<sub>3</su…